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Correlation Of Serum Calcium Level with Gold Criteria in Chronic Obstructive Pulmonary Disease Patients in A Tertiary Care Centre Tamaka Kolar

2025-06-01T00:00:00Z

Title: Correlation Of Serum Calcium Level with Gold Criteria in Chronic Obstructive Pulmonary Disease Patients in A Tertiary Care Centre Tamaka Kolar Authors: Prem chandar reddy, sangam; Raveesha, A2*; Vidyasagar, CR; Manohar Gowda, B G Abstract: Introduction Patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) are at increased risk for morbidity and mortality compare to non-exacerbators. Electrolyte imbalances with calcium is most often reported in these patients. Correlation between serum calcium levels and GOLD (Global Initiative for Chronic Obstructive Lung Disease) criteria remains unclear. Aims and objectives This study aims to correlate serum calcium levels in acute exacerbation of COPD patients with GOLD criteria. Materials and Methods Forty-eight (48) patients with acute exacerbation of COPD were included in the study. Serum calcium levels were defined as per recent guidelines.Statistical analysis was performed using SPSS version 22. Results A total of 48 patients were included in which majority of people were between the ages 61and 70. The mean serum calcium levels were lower in patients with acute exacerbation of chronic obstructive pulmonary disease in which very low serum calcium level correlated with severe grade of GOLD criteria(viceversa) with significant p value of <0.05. Conclusion Our study indicated that hypocalcemia was associated with an elevated risk of COPD exacerbation.Hypocalcemia was correlated with GOLD criteria, the low the serum calcium level the severe the GOLD criteria.

Efficacy and safety of botulinum toxin as a non‑surgical option for upper eyelid retraction in active thyroid‑associated ophthalmopathy: a prospective interventional study

2025-07-01T00:00:00Z

Title: Efficacy and safety of botulinum toxin as a non‑surgical option for upper eyelid retraction in active thyroid‑associated ophthalmopathy: a prospective interventional study Authors: Vinay Kumar, Sonali; Mishra, Sanjay Kumar; Sati, Alok; V. Kumar, Natasha Abstract: Aim This study evaluates the efficacy and safety of botulinum toxin injection for the treatment of upper eyelid retraction in patients with active thyroid-associated ophthalmopathy (TAO).

Early detection of cardio toxicity in organophosphorus poisoning

2023-04-01T00:00:00Z

Title: Early detection of cardio toxicity in organophosphorus poisoning Authors: Dr. Raveesha., A; Dr. Anitha., A; Dr. Shashidhar., K.N; Dr. Suresh., T.N; Dr. Minni, Meka; Dr. Meghashri., V Abstract: Introduction: The widespread use and easy availability of organophosphorus(OP) and carbamates as agricultural insecticides has increased the likelihood of poisoning with these compounds in developing countries. Organophosphate poisoning has been postulated both in animal and human studies to cause myocardiotoxic damage (myocardial necrosis).Cardiac complications often accompany poisoning with these compounds, which may be serious and often fatal. These complications are potentially preventable if they are recognised early and treated adequately. Objective: To detect early cardiotoxicity in organophosphorus poisoning by using, troponin-T, ECG and serum electrolyte levels. Methodology: A prospective observational study carried out from January 2019 to January 2020 and total of 110 adult patients with consumption of OP compound were included after satisfying the inclusion criteria. Electrocardiogram(ECG) was recorded as soon as patient presented to emergency department and daily. Cardiac activity was monitored using cardiac monitor and additional ECG was recorded if required. Blood samples was drawn on 1st ,3rd and 5th day of admission for cardiac enzymes ( trop-I) and electrolyte estimation (Na+, K+, Ca2+). Conclusion: Cardiac markers like Trop I can be used as an early predictor of cardiotoxicity in OP poisoning patients. Dyselectrolytemia recognized early can be corrected and is reversible which can prevent mortality in organophosphorus poisoning patients.

Correlation of Six Minute Walking Test, Sit to Stand Test and Pulmonary Function Test in Patients with Chronic Obstructive Pulmonary Disease

2023-01-01T00:00:00Z

Title: Correlation of Six Minute Walking Test, Sit to Stand Test and Pulmonary Function Test in Patients with Chronic Obstructive Pulmonary Disease Authors: Meghashri., V; Raveesha, A.; Guruprasad., T J; Charchit, Mehta.; Deepthi, Manchu Abstract: Introduction: Assessment of functional capacity in Chronic Obstructive Pulmonary Disease (COPD) patients helps in determining the severity of the disease. While spirometry is the gold standard, six Minute Walk Test (6MWT) and one minute Sit To Stand Test (STST) are simple and practical tests to assess exercise capacity and physical condition. Aim: To find the diagnostic accuracy of these of 6MWT and one minute STST in comparison with spirometry. Materials and Methods: This cross-sectional study was conducted in the Department of General Medicine at Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India, from January 2019 to December 2019. All cases of COPD diagnosed using GOLD 2018 criteria were included in the study. Patients performed 6MWT and one minute STST. Heart rate, blood pressure, oxygen saturation, SpO2, dyspnoea, and fatigue (Borg scale) were noted pretest and post-test. The sensitivity, specificity, predictive values and diagnostic accuracy of the screening test with the decided cut-off values along with their 95% CI were presented. A p-value <0.05 was considered statistically significant. Results: The mean age of the patients was 64.09±8.31,while there were 112 (94.9%) males and 6 (5.1%) female. Overall, 81.54% of the participants had severe/very severe COPD group, walked <332.49 meters, and only 18.46% could walk more than 332.50 m. The SpO2 decreased from 93.98±0.82 to 91.75±1.39. During the one minute STST, SpO2 decreased from 93.98±0.82 to 91.75±1.39. A positive correlation was observed between the one minute STST, and it had good predictive validity in predicting COPD, as compared with spirometry {Area Under the Curve (AUC) of 0.915 (95% CI 0.866 to 0.963, p-value <0.001)}. 6MWT has a sensitivity of 81.54%, the specificity of 79.25%, and one minute STST had a sensitivity of 89.23%, specificity of 67.92% in predicting COPD. Conclusion: In a remote clinical setting, where spirometry is not available, 6MWT and one minute STST are the best methods for assessing COPD severity.