DSpace Collection:

Dermatology Photo Quiz 1

Mon, 01 May 2023 00:00:00 GMT

Title: Dermatology Photo Quiz 1 Authors: Rajashekar., T S; Suresh Kumar, K.; Harish Prasanna, R.; Hussain, Kolsawala.; Sumedha, Tirthani.; Hanumanthayya, K Abstract: Contact dermatitis (CD) is commonly seen in the dermatology OPD cases. 10 to 20% of all new cases will be suffering from contact dermatitis. The simple meaning of contact dermatitis is, when a substance come in contact with the skin, the substance may directly damage the skin by its cytotoxic effect, or by stimulating immune competent cells to attack skin and cause damage to the skin. Acids like HCL, HNO3, H2SO4 and alkalis like dish washing soaps, detergents, ammonia, potassium hydroxide, sodium hydroxide and cow urine will damage the skin immediately, and the resultant skin damage is called “Irritant Contact Dermatitis (ICD)”. Some substances of smaller molecular weights (haptens, 500 to 1000 nm) will penetrate the skin, combine with tissue proteins, and then the antigenicity of tissue protein will get altered, the antigen presenting cell will take up this altered molecule, processes it and present it to immune competent cell CD4+T Lymphocyte. Activated CD4+T lymphocyte will proliferate, few become memory cells, and few become sensitized cells. If same hapten come in contact with the body second time, immune competent cells will react aggressively, person will develop inflammation of skin. This reaction is called “Allergic Contact Dermatitis (ACD). Here we are reporting a case of ICD.

A Comparative Study of Topical Procapil With Platelet-Rich Plasma Therapy Versus Topical Redensyl, Saw Palmetto, and Biotin With Platelet-Rich Plasma Therapy in the Treatment of Androgenetic Alopecia

Mon, 01 May 2023 00:00:00 GMT

Title: A Comparative Study of Topical Procapil With Platelet-Rich Plasma Therapy Versus Topical Redensyl, Saw Palmetto, and Biotin With Platelet-Rich Plasma Therapy in the Treatment of Androgenetic Alopecia Authors: Pavithra., T R; Rajashekar, T S; Suresh Kumar, K.; Harish Prasanna, R Abstract: Background and aim Androgenetic alopecia (AGA) is a well-known hair loss disorder in both men and women affecting approximately 80% and 50% of the population, respectively. Various treatment options for AGA are available with varying efficacy. Combination therapy is a new dictum to combat AGA. Hence, this study aimed to compare the efficacy of commonly used topical therapies such as Procapil with platelet-rich plasma (PRP) and redensyl, saw palmetto (SP), and biotin (RSB) with PRP. Materials and methods This was a randomized controlled trial conducted on 54 male patients with AGA attending the outpatient department in a tertiary care hospital. Participants were randomly assigned into two equal groups (A and B). Group A participants were treated with Procapil with PRP, and group B participants were treated with redensyl, saw palmetto, and biotin with PRP at three weeks intervals for a total period of four sessions. Clinical improvement was assessed by serial hair photography by a third blinded observer and was recorded. Results A total of 54 individuals were included and were distributed into 27 each in group A and group B. AGA grading score was found significant between the groups with P < 0.05. Conclusion PRP with adjuvants redensyl, saw palmetto, and biotin can be a better alternative to the current therapies of PRP.

A Comparative Study of Intralesional Acyclovir vs Immunotherapy for Treatment of Viral Warts

Mon, 01 May 2023 00:00:00 GMT

Title: A Comparative Study of Intralesional Acyclovir vs Immunotherapy for Treatment of Viral Warts Authors: Meghana Reddy., Endela; Rajashekar., T S; Suresh Kumar, K Abstract: Background: Viral warts are caused by human papillomavirus (HPV), are difficult to treat with conventional modalities, and are cosmetically disfiguring; hence, immunomodulators are being used. The viral origin of warts suggests the antiviral drug acyclovir as a potential therapeutic option. The current study compares the effect of intralesional acyclovir (nucleoside analogue) and intralesional purified protein derivative (PPD) (immunotherapy) in treating various viral warts. Methodology: Prospective observational comparative study was conducted to determine the efficacy of acyclovir, and PPD administered via the intralesional route in patients with viral warts. The study population was categorized into two groups. One group received intralesional acyclovir, and the other received intralesional PPD. Patients were followed-up with for three months. Outcomes considered in our study were recovery (complete, partial, and no recovery) and side effects like pain, burning sensation, and desquamation. Statistical analysis was carried out by coguide software. Results: In our study total of 40 participants, 20 in each group were included. 25 and 15 were of age <30, and ≥ 30, respectively, while 20 were males, and 20 females. Our study reported 60%, and 30% of complete recovery with intralesional acyclovir treatment and intralesional PPD treatment, respectively, in the twelfth week. However, p-value > 0.05 represented no significance between groups. 90% in the acyclovirtreated group presented with pain, and 100% presented with burning sensation, while in the case of PPDtreated group, 60% presented no side effects and the rest 40% showed pain. Conclusions: Intralesional acyclovir is more effective in treating viral warts than PPD. The focus is to be laid on anticipated side effects.

A Clinicoepidemiological Study of Cutaneous and Systemic Comorbidities of Seborrheic Dermatitis in Adolescent and Adult Females

Thu, 01 Jun 2023 00:00:00 GMT

Title: A Clinicoepidemiological Study of Cutaneous and Systemic Comorbidities of Seborrheic Dermatitis in Adolescent and Adult Females Authors: Rajashekar., T S; Savana, Waikhom.; Suresh Kumar, K.; Meghana Reddy, Endela Abstract: Background Seborrheic dermatitis is the most common, chronic inflammatory skin condition which is confined to the scalp, nasolabial folds, and regions rich in sebaceous glands for which no definitive cause has been found. Although the disease is more common, the comorbidities associated with it have not been studied in detail. This study aims to assess the prevalence of seborrheic dermatitis and its associated cutaneous and systemic comorbidities in adolescent and adult patients. Methodology This cross-sectional study was performed among 451 adolescent and adult female patients who visited the Department of Dermatology, Venereology, and Leprosy of R. Laxminarayanappa Jalappa Hospital and Research Centre, Kolar. Patients having symptoms such as scaly patches, inflamed skin, and stubborn dandruff were diagnosed with seborrheic dermatitis and included in the study. A detailed history was collected for assessing other cutaneous disorders. Results Out of the 451 female participants, 87% belonged to the age group of 21-30 years, with 60.9% having cutaneous and 28.3% having systemic comorbidities. Acne (13.3%) and diabetes mellitus (13.1%) were the most common cutaneous and systemic associated comorbidities, respectively. Conclusions Comorbidities of seborrheic dermatitis were more commonly seen in adult female patients, Some of the common cutaneous comorbidities were acne, alopecia areata, and folliculitis. Systemic comorbidities included diabetes, obesity, and hypertension. However, all of these comorbidities were not statistically significant.