A Comparative study of usefulness of topical placental extract versus topical colloidal silver in the management of Diabetic Foot Ulcer.

Abstract

Background: Diabetic foot is defined as a group of syndromes in which neuropathy, ischemia and infection with multidisciplinary approach with conventional treatment lacking necessary growth factors so to augment healing process. The aqueous form of placental extract contains numerous growth factors and antimicrobial action of nano particles of colloidal silver augmenting tissue regeneration. Objectives: To compare the effectiveness of both in terms of decrease in the size of ulcer and duration of ulcer healing in the management of diabetic foot ulcers. Study design: The study is a randomized prospective study conducted in R.L. Jalappa Hospital and research center from December 2018 to December 2020. Methodology: A total sample of 60 divided into two group by even and odd method.Patient with DFU satisfying inclusion criteria were included in the study. Placental extract of 0.25% concentration topical application for group A and colloidal silver of 0.002% concentration of topical application for group B patient were applied with dressing being changed daily. The weekly observation of ulcer in term of reduction in size, appearance of granulation tissue and clearance of necrotic tissue and was measured and recorded. Results: Placental extract application in DFU shows better healing rates in term of reduction in size, appearance of granulation tissue and reduction of necrotic tissue than colloidal silver. Conclusion:The use of placental extract showed better response in terms of ulcer size reduction, appearance of granulation tissue and clearance of necrotic tissue.HbA1c has a linear association in healing of ulcers.