COMPARISON OF INTUBATION RESPONSE WITH DEXMEDETOMIDINE NEBULISATION AND INTRAVENOUS DEXMEDETOMIDINE

Abstract

Background: In order to avoid undesirable outcomes during laryngoscopy and intubation, hemodynamic response must be attenuated. Dexmedetomidine is an excellent drug used to manage the pressor response. Various routes of administration have been documented with paucity of studies on the nebulized dexmedetomidine. Aim: The purpose of this research was to compare the hemodynamic responses to intubation with intravenous and nebulized dexmedetomidine. Methods: Among 98 patients ranging in age from 18 to 60 years old and classified as ASA-I or II, a prospective comparison research was carried out. They were split into two groups: one that received dexmedetomidine by nebulization (N = 49) and another that received it intravenously (N = 49). SBP, DBP, MAP, and HR were measured before induction (at baseline and 10 minutes) and after induction (1st, 3rd, 5th, 7th, and 10th minutes). The agent was given 15 minutes before to induction. Intubation time was also recorded. Results: No statistically significant differences in hemodynamic indicators were seen between the groups up to the third minute. Results showed that the nebulized group's diastolic blood pressure (BP) and HR remained significantly elevated until the tenth minute. The duration of intubation was similar. Conclusion: The results show that all hemodynamic parameters are dramatically reduced after 3 minutes of intubation and laryngoscopy when nebulized dexmedetomidine is administered. However, post 3 minutes, nebulized dexmedetomidine could successfully attenuate only SBP and MAP and failed to attenuate DBP and HR.