AN OBSERVATIONAL STUDY OF TRIGLYCERIDE GLUCOSE INDEX AS A PROGNOSTIC MARKER IN ELDERLY HYPERTENSIVE PATIENTS WITH ACUTE ISCHEMIC STROKE IN TERITIARY CARE CENTRE

Abstract

Introduction: A primary cause of morbidity and death is ischemic stroke,especially within elderly hypertensive patients. Insulinresistance,risk factor, is linked to cerebrovascular events. The triglyceride-glucoseindex (TyG) be a reliable marker for Insulin resistance, linked to metabolic disorders like diabetes and cardiovascular diseases. However, its prognostic significance in elderly hypertensive patients with acute ischemic stroke remains underexplored. Materials and Methods:The present prospective observational study took place on 64 patients in the department of general medicine, RL Jalappa Hospital and Research Centre, Kolar, temporarily of 18 months from july 2022 to december 2023. Prior to the initiation of the study, Ethical and Research Committee clearance was obtained from Institutional Ethical Committee. Results and observations: The study analyzed the prevalence of hypertensives among individuals aged 71-80 years, with a majority of subjects being males (54.69%), predominantly from urban areas (64.06%), predominantly Hindus (30.06%), Muslims (32.81%), Christians (21.87%), and other religions (6.25%). The majority of subjects were of high socioeconomic status (54.69%), with a history of hypertension (100 %) . The fasting triglyceride levels were 167.5±15.1 mg/d, and the triglyceride glucose index was 8.9±0.6. The study found significant differences in blood pressure, stroke recurrence, poor functional outcome, neurological worsening, and mortality rates among the groups based on the triglyceride glucose index. The Incidence of Stroke recurrence was high in group IV, poor functional outcome was high in group III, neurological worsening was high in group IV, and mortality was high in group IV. Conclusion: The Ty GLUCOSE index, a risk factor for stroke mortality and recurrence, is linked to higher risk in Hypertensive patients. However, neither TG index nor HOMA-IR can accurately predict stroke death or recurrence in nondiabetic acute ischemic stroke patients. The TyG index may be useful for assessing risk in the broader community. High TG index correlates with unfavorable consequences after a stroke, including increased mortality and stroke recurrence. The TG index's linearity suggests it could improve ischemic stroke risk classification for the general population.