“LYMPHOCYTE/MONOCYTE RATIO COMPARED WITH MELD-SODIUM AND CHILD PUGH SCORING SYSTEMS IN LIVER CIRRHOSIS PATIENTS

Abstract

Introduction: Cirrhosis is a common liver disease causing abnormal tissue replacement, leading to advanced hepatic injury and potential end-stage liver failure or cancer. Hepatologists struggle to develop reliable prognostic scores for patients with liver cirrhosis. This study aims to assess the ‘lymphocyte-to-monocyte ratio (LMR)’ in comparison to ‘MELD’ and ‘Child-Pugh scores’. Materials and Methods:The present ‘prospective observational study’ was conducted on 136 patients suffering from liver cirrhosis in ‘Sri devraj URS academy of higher education and research’ for a period of 24 months from June 2022 to September 2024.Prior to the initiation of the study, Ethical and Research Committee clearance was obtained from Institutional Ethical Committee. Results and observations: The study involved 136 male subjects aged 41-50 years, most with alcoholism. The majority had hepatitis virus and steatosis, diagnosed within 0-5 years. The subjects had symptoms like fatigue, anorexia, jaundice, insomnia, leg edema, and more. Most belonged to Group C, with the highest lymphocyte to monocyte ratio in Group A. Conclusion: The study found that ‘lymphocyte/monocyte ratios (LMR)’ could be a useful bio-marker for measuring liver cirrhosis severity, potentially complementing or surpassing established grading systems like ‘MELD-Na’ and ‘Child-Pugh’. However, further research is needed to validate these findings and investigate the clinical consequences of introducing ‘LMR’ into standard diagnostic processes.