THE ROLE OF HbA1C AS AN EARLY PREDICTOR OF GESTATIONAL DIABETES MELLITUS IN EARLY PREGNANCY- A PROSPECTIVE STUDY

Abstract

BACKGROUND: Gestational Diabetes Mellitus (GDM) that starts or is first identified during pregnancy is known as gestational diabetes mellitus (GDM). Universally, gestational diabetes influences 90% of pregnant ladies. One out of ten pregnancies is connected to diabetes. Fetal and maternal results might be extreme in the event that gestational diabetes is either misdiagnosed or not oversaw as expected. A few examinations, nonetheless, have shown that the two moms and offspring of GDM ladies are at increased risk for creating type 2 diabetes later on. Rates of GDM are a lot higher in India, quite possibly of the most populated country on the planet, with gauges going from 10.3 to 14.3 percent.

AIM AND OBJECTIVES: To evaluate the HbA1c in all to begin with first trimester pregnant women. To assess the connection of HbA1c in early pregnancy (8-12 weeks) and expectation of development of diabetes mellitus in second trimester (24-28 weeks) of pregnancy with oral glucose tolerance test (OGTT).

METHODS: Seventy-five pregnant ladies going to the OB/GYN facility at Sri Devaraj Clinical School in Kolar, D.t., Karnataka's RL Jalappa medical clinic were the subjects of our forthcoming observational exploration. To gauge HbA1C and fasting blood glucose levels in the primary trimester, analysts submitted blood tests from all pregnant ladies who partook in the review. Between weeks 24 and 28, they had a 75 g OGTT, which is a normalized, one-step test. xx

RESULTS: Majority of study members are old enough gathering <25yrs comprising 40(53.33%). Among every one of the members 57 (76%) were viewed as with typical HbA1c. Out of 18 ladies with unusual HbA1c values larger part 10(14.28%) have a place with 25-35 age bunch with P esteem viewed as 0.005 which is measurably huge. Comparatively with the movement old enough the frequency of GDM is likewise increasing with X2 esteem being 18.66 and P esteem <0.001 with high importance. Larger part of the ones who were signed up for the review were Primigravida 46 (61.33%). With increase in equality poor glycaemic control is seen with X2 esteem being 9.68 and P esteem 0.002 which is huge. Frequency of GDM is increased with equality with P esteem <0.001 with high importance. It was observed that there is no relationship between's financial status and event of GDM. ROC Bend for HbA1c in first trimester in anticipating GDM viewed as exceptionally critical with P worth of <0.0001. Huge cut off HbA1C esteem in foreseeing diabetes mellitus by OGTT was viewed as 5.7 (with Awareness is 100 percent and Misleading energy rate is 0%)

CONCLUSION: Estimation of HbA1c in first trimester is a good predictor for occurrence of GDM in second trimester. Life style modification and Medical nutrition therapy can be advised to those women who are with poor glycemic control in first trimester there by preventing the complications of GDM later in pregnancy, intrapartum and postpartum. This may also prevent occurrence of DM in progeny.