ATTENUATION OF PRESSOR RESPONSE TO PNEUMOPERITONEUM IN LAPAROSCOPIC SURGERIES, COMPARISON BETWEEN MAGNISIUM SULPHATE AND DEXMEDETOMIDINE: A RANDOMISED CONTROL STUDY

Abstract

Background: Laparoscopic surgeries, favored for their minimally invasive nature and quicker recovery, often involve the creation of a pneumoperitoneum using carbon dioxide (CO₂). Aim: To evaluate and compare the effectiveness of magnesium sulfate and dexmedetomidine in controlling the hemodynamic pressor response to pneumoperitoneum during laparoscopic surgeries. Materials and Methods: “This study was conducted on 56 patients undergoing laparoscopic surgeries under general anesthesia at R.L. Jalappa Hospital from May 2023 to October 2024. Patients were randomly divided into two groups: Group B got 1 mcg/kg dexmedetomidine and Group A received 50 mg/kg magnesium sulfate, all of which were administered in 100 ml of normal saline over 20 minutes before to induction. Systolic and diastolic blood pressure, heart rate, and mean arterial pressure were measured at baseline and at regular intervals during the procedure. SPSS 20.0 was utilized to conduct the statistical analysis.” Results: Both groups were demographically comparable. Dexmedetomidine (Group B) resulted in significantly lower systolic, diastolic, and mean arterial pressures at the 1st minute and maintained a more stable heart rate throughout surgery. Magnesium sulfate (Group A) showed higher early intraoperative blood pressure and heart rate, though later stabilized. Conclusion: Both dexmedetomidine and magnesium sulfate effectively attenuate the pressor response during laparoscopic surgeries. However, dexmedetomidine offers superior hemodynamic stability and may be preferred in patients at higher cardiovascular risk.